Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases

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Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases

BACKGROUND We report 3 patients with laser-induced choroidal neovascularization (CNV). METHOD Retrospective, observational case series. Medical charts and photographs were reviewed. RESULTS Two patients with central serous chorioretinopathy who developed iatrogenic CNV after focal laser photocoagulation were treated with intravitreal ranibizumab injections. One patient with CNV secondary to...

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Pafhogenesis of Laser-Induced Choroidal Subrefinal Neovascularization

The early stages (1 day to 3 weeks) in the development of laser-induced choroidal subretinal neovascularization were studied in the monkey eye. Histopathology revealed that the intense laser beam disrupted the choroid/Bruch's membrane/retinal pigment epithelium (RPE) complex and initiated a repair process. Although all lesions received the same energy density, the initial choroidal wound varied...

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IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization

Choroidal neovascularization (CNV) is aberrant angiogenesis associated with exudative age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Inflammation has been suggested as a risk factor for AMD. The IKK2/NF-κB pathway plays a key role in the inflammatory response through regulation of the transcription of cytokines, chemokines, growth factors and angiogenic fac...

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Quantitative image analysis of laser-induced choroidal neovascularization in rat.

Rodent models of laser-induced choroidal neovascularization (CNV) are now extensively used to identify angiogenic proteins, determine the role of specific genes with knockout mice, and evaluate the efficacy and safety of anti-angiogenic therapies. CNV is typically evaluated by fluorescein angiography or vascular endothelial cell labeling in histologic sections. The current study examined an alt...

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Investigation of laser-induced choroidal neovascularization in the rat.

PURPOSE Choroidal neovascularization plays an important role in pathogenesis of age-related macular degeneration. Induction of neovascularization by laser photocoagulation in the rat fundus is an established animal model in which the effects of new therapeutic approaches are assessed. The purpose of this study was to compare different detection methods of laser-induced neovascularization in the...

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ژورنال

عنوان ژورنال: Case Reports in Ophthalmology

سال: 2017

ISSN: 1663-2699

DOI: 10.1159/000479308